Arizona Cardinals +6.5 (-110)

Arizona’s offense will be prolific this year. Kyler Murray finally has an alpha receiver again and he should unlock the offense. This is a tough ask for Arizona to go into Buffalo and win. Luckily, they just need to keep it under a touchdown. Josh Allen will be able to find holes and exploit what is a generally bad Arizona defense, however, Josh Allen doesn’t play defense. The Bills have lost almost all of their veteran presence on defense. This might turn into a shootout where Arizona might make it hard on the Bills in the opener.