San Francisco 49ers -7 (-110)
I am fully aware how square this play is. Laying 7 in any game is bad, let alone in a divisional game. Also, I have the Niners that blew out a team last week, playing a team that was blown out. This should favor Arizona. Also, the Niners have a short week next week, playing a divisional opponent on the road. All these things should favor Arizona. And normally, I would favor Arizona given those factors. However, in a weird twist, everything else in this game favors the Niners. San Fran is anywhere from the best to the 4th best team in the NFL and is playing at home against one of the worst defenses. The offense is basically all healthy (minus CMC). The defense should have a huge advantage against an awful Arizona offensive line. Every measurable tangible favors the Niners. Every intangible favors Arizona. Let’s go with science/math over gut. Gimmie the Niners.